Hilbert’s problems form a list of twenty-three problems in mathematics published by German mathematician David Hilbert in 1900. The problems were all unsolved at the time, and several of them were very influential for 20th century mathematics. Hilbert presented ten of the problems (1, 2, 6, 7, 8, 13, 16, 19, 21 and 22) at the Paris conference of the International Congress of Mathematicians, speaking on 8 August in the Sorbonne. More unsolved mathematical problems.

Dilbert‘s problems represents an ongoing online effort to compile a list of outstanding bioinformatics related problems/challenges:

- Carry out comparative genomics of whole genomes of multiple organisms
- Simulate the assembly processes of entire cellular organelles like Chromatophores and Ribosomes as well as Membrane Proteins or Viral Capsids, which consist of a few million atoms
- Simulate the folding of chaperones on functionally relevant time scales
- Compute all possible motifs in the entire human genome
- Correlate large-scale gene expression data with sequence information to have a better understanding of gene regulation at the whole organism level
- Simulate all the metabolic networks in the whole organism and understand the various regulatory networks
- Simulate an entire cell or an organism from the systems biology perspective

Choosing first problem is one of the greatest… problems for beginners, since SPOJ gives you access to a vast problem archive.

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